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Fig. 6 | Genome Biology

Fig. 6

From: An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Fig. 6

Regulatory role of HNF4α in colon epithelium. a GSEA analysis of target gene sets of HNF4α. b Distance of HNF4α binding sites to the nearest TSS. c The average, normalized ChIP-seq signal in HFDHFB and HFDLFB groups at gained HNF4α binding sites that were identified in HFD and LFD groups. d Genome browser tracks showing HNF4α occupancy near Fmo1 and Fmo2. e Normalized counts of transcripts for Fmo1 and Fmo2 in HFDHFB and HFDLFB groups. f Genome browser tracks showing HNF4α occupancy near the Scd1 locus. g Normalized counts of transcripts for Scd1 in HFDHFB and HFDLFB groups. h Genome browser tracks showing HNF4α occupancy near Sulf2. i Normalized counts of transcripts for Sulf2 in HFDHFB and HFDLFB groups. P value from DESeq2, p < 0.05; p < 0.01; p < 0.001; p < 0.0001

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