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Fig. 2 | Genome Biology

Fig. 2

From: An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Fig. 2

Diet and obesity altered the host transcriptome and epigenome. a Numbers of active (marked with both H3K27ac and H3K4me1) and poised enhancers (marked with H3K4me1 only) in obese and lean mice. b Overlap analysis of active enhancers and active promoters in obese and lean mice. c Expression levels at genes with none, poised, or active enhancers in colonic epithelium from animals on HFD. d Expression levels at genes with none, one, or more than one active enhancer in colonic epithelium in animals on LFD. e Oncomine analysis of differentially expressed genes from animals on HFD compared to differentially regulated genes from normal colon, normal rectum, and colon mucinous adenocarcinoma (groups 1, 2, and 3, respectively). f Heatmap of different enrichment loci of H3K27ac and H3K4me1 from colonic epithelium in mice on different diets. g Representative genome browser shot of differentially enriched loci of H3K27ac and H3K4me1 from colonic epithelium in mice on different diets. h Proportion of genes with different distances from differentially enriched loci for H3K27ac and H3K4me1 to transcription start site. i, j IPA analysis of differential enrichment loci of H3K27ac (i) and H3K4me1 (j). k, l Motif analysis of differential enrichment loci of H3K27ac (k) and H3K4me1 (l). p < 0.0001

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