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Fig. 6 | Genome Biology

Fig. 6

From: Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

Fig. 6

Graphical abstract - Wnt/beta-catenin activation affects neighbouring cells. Epidermal cells in culture adopt one of five distinct transcriptomic states differing on the basis of proliferation and commitment to differentiation. Wnt/beta-catenin signalling acts as a non-cell autonomous signalling cue to activate a handful of TFs including Smad3/4, E2f1/4 and Bcl3 in neighbours. Concurrently, transcriptional heterogeneity is reduced as neighbour cells enter into a committed and proliferative transcriptional state

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