Fig. 6

Sites of epigenetic supersimilarity (ESS) and systemic interindividual variation (SIV) are enriched for effects of periconceptional environment on DNA methylation. a Relative to all probes on the HM450 array, mQTL-filtered ESS and SIV probes (but not negative control probes) are highly enriched for significant (FDR < 10%) associations with season of conception in rural Gambia. b Heat map of average effect of season of conception at loci that show a significant seasonal difference in methylation (FDR < 10%). At both ESS and SIV probes, as in previous studies of MEs in independent cohorts [13, 14], children conceived in the rainy season have higher methylation