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Fig. 3 | Genome Biology

Fig. 3

From: Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development

Fig. 3

Integration of LungNet with promoter DNAm patterns. a Color bars indicate the mean relative TF activity for the 38 lung-specific TFs as estimated in the Illumina 450 k DNAm dataset for lung tissue and all other tissues combined. TFs have been sorted in decreasing order of significance with those in bold attaining statistical significance (P < 0.05). b Boxplot of t-statistics of differential TF-activity between lung and all other tissues for the 38 lung-specific TFs against the corresponding statistics for the case where the targets in LungNet were randomized. P values are from Wilcoxon rank sum tests. c Boxplots of estimated relative TF-activity levels between lung and all other tissues for the six top-ranked TFs. d Color bars comparing the promoter DNAm levels of the 16 TBX4 targets between lung and all other tissues, with t-test P values shown in lower color bar

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Genome Biology

ISSN: 1474-760X

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