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Fig. 5 | Genome Biology

Fig. 5

From: Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

Fig. 5

Infiltration of blood-derived TAMs varies by glioma molecular subtype and correlates with inferior survival. a Z-scores of averages over blood-derived (top) and microglial (bottom)-TAM signature genes, compared across glioma subtypes (n = 371 cases, 117 oligodendrogliomas [OLIGs], 110 astrocytomas [ASTROs], 144 GBMs). CLS classical, MES mesenchymal, PN proneural. Significance was assessed via Tukey’s range test. NS indicates the test is not significant at p = 0.05. b Kaplan–Mayer survival curves, based on LGG TCGA RNA-seq for which survival information is available (n = 363 cases). Gene expression was averaged over the blood-derived and microglial signature genes, respectively, to assign a signature score to each case. The median signature score was used to divide cases into high-expressing and low-expressing cohorts. All comparisons were adjusted for age and gender, using cox proportional-hazards regression. HR hazard ratio

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Genome Biology

ISSN: 1474-760X

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