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Fig. 4 | Genome Biology

Fig. 4

From: Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

Fig. 4

Markers of ontogeny from human TAMs also separate brain-derived perivascular macrophages from microglia in scRNA-seq of mouse and human non-malignant cortex. A PCA of human TAMs (orange/pink, n = 1416 cells), human microglia from non-malignant cortex (purple, n = 17 cells), murine microglia from non-malignant cortex (blue, n = 33 cells), and murine perivascular macrophages from non-malignant cortex (red, n = 65 cells). PCA was performed in the space of 87 genes that are differentially expressed between murine-TAM lineages and robustly measured across all datasets (mean CPM > 1 in all datasets)

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Genome Biology

ISSN: 1474-760X

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