From: Evaluation of in silico algorithms for use with ACMG/AMP clinical variant interpretation guidelines
Algorithms (n) | Algorithms | Overall true concordance (%) | Overall false concordance (%) |
---|---|---|---|
2 | REVEL, MetaSVM | 83.4 | 7.8 |
3 | VEST3, REVEL, MetaSVM* | 75.6 | 4.1 |
4 | Polyphen2, REVEL, MetaSVM, Eigen* | 69.3 | 4.1 |
5 | Provean, Polyphen2, REVEL, MetaSVM, Eigen | 64.5 | 3.2 |