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Fig. 3 | Genome Biology

Fig. 3

From: Evaluation of in silico algorithms for use with ACMG/AMP clinical variant interpretation guidelines

Fig. 3

Performance analysis of algorithms. The AUC of a ROC are plotted for 25 algorithms. Vertical dotted line indicates an AUC of 0.9 and 99% confidence intervals for each AUC are shown. Blue dots indicate AUC > 0.89. a AUCs of the algorithms across different datasets shown in the panels and described in text. b AUCs of the algorithms across different datasets (represented in panels) to address type I circularity as described in text. The same plots for ClinVar Status * and ClinVar Status ** as in Fig. 3a are used in 3b for comparison. Any instance of ** represents variants with ClinVar review status of two stars or above.   Ensemble predictors are indicated by dark green labels on the y-axis

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