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Fig. 3 | Genome Biology

Fig. 3

From: Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats

Fig. 3

Defective spatial novelty detection and spatial working memory in Stau2KD rats. a NOL task is schematically represented (top); preference for the novel object in the hippocampus-dependent NOL task for Tx-treated Stau2KD (black; n = 12) and CaMKIIα-CreERT2 (gray; n = 8) rats (NOL: F genotype (1,18) = 4.47; p = 0.049). Values > 50% indicate that the animals spent more time investigating the novel object during the study phase. bd DMTP water maze task. Schematic representation of the DMTP task (b), consisting of four trials each day (T1–T4). Within a particular day, the position of the escape platform (dot) was fixed, but changed to a different position between days. During initial training and testing, the delay interval between all daily trials was 1 min (Ph 1). Subsequently, only the delay interval between T1 and T2 was extended to 30 min (Ph 2) or 6 h (Ph 3). Latency in T2 to find the escape platform, expressed as percentage of the initial training trial T1 (c) and the latency to reach the platform zone (platform plus surrounding area) during the probe trial on T2 (d) for CaMKIIα-CreERT2 and Stau2KD animals (n = 12 animals/group). e, f Schematic representation of DNMTP eight-arm radial maze task (e). Plots indicating the percentage of animals that make the correct arm choice during the choice phase of the DNMTP task after short (1 min) and intermediate (5 min, 10 min) time delays for CaMKIIα-CreERT2 (n = 6) and Stau2KD animals (n = 8) (F genotype (1,36) = 21.12; p < 0.001). Figures show mean + or ± SEM. Stars represent p values between genotypes obtained by either t-test (a, c, d) or Bonferroni post hoc analysis following two-way ANOVA of repeated measures (f). Hashtags represent p values of one-sample t-tests to chance level 50%: * p < 0.05; ** p < 0.01; ***,### p < 0.001

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