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Fig. 2 | Genome Biology

Fig. 2

From: Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats

Fig. 2

Stau2 deficiency leads to synaptic strengthening. ad Representative fEPSPs (a, c, top) and averaged potentiated responses (a + c, bottom) following 600 pulses at 200 Hz (high-frequency stimulation [HFS], a) or 900 pulses at 1 Hz (low-frequency stimulation [LFS], c) of the PP in Tx-injected CAG-STOP-miR(Stau2) (white), CaMKIIα-CreERT2 (gray), or Stau2KD rats (black) recorded in CA1. Displayed fEPSPs were taken at time points B, 1, and 2 indicated in the figure. Quantitative analysis of fEPSPs following HFS (b) or LFS (d). e Averaged potentiated responses recorded in CA1 on day 1 following stimulation with either LFS or HFS (left) and illustration of postulated frequency-response functions of hippocampal synaptic plasticity in CaMKIIα-CreERT2 (gray) and Stau2KD rats (black) according to the BCM frequency-response function for the data points recorded in CA1 (right). Statistical significant differences within groups are indicated using horizontal bars with circles, and between groups with stars after two-way ANOVA of repeated measures and all pairwise multiple comparison procedures (Holm–Sidak method) (n = 10 animals/group). *, p < 0.05

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