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Fig. 3 | Genome Biology

Fig. 3

From: The multidimensional mechanisms of long noncoding RNA function

Fig. 3

Long noncoding RNAs (lncRNAs) regulate gene expression by interacting with DNA-binding proteins. a The lncRNA GAS5 interacts with the activated glucocorticoid receptor (GR), which, following the binding of its ligand and the lncRNA, dissociates from heat-shock proteins (HSPs) and translocates to the nucleus. GAS5–GR interaction prevents GR from binding to the glucocorticoid-response elements (GRE) contained in responsive genes [58]. b DNA-damage-activated tumour suppressor protein p53 induces the transcription of the lncRNA DINO, which, in turn, binds and stabilizes p53, promoting the binding of the transcription factor to the p53-response elements (PRE) of target genes [59]

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