Fig. 2
From: The fitness cost of mis-splicing is the main determinant of alternative splicing patterns
Impact of NMD on observed AS rates. AS events (IR or cryptic intron splicing) are classified into three groups according to their NMD-visibility: PTC-inducing events (i.e. NMD-visible); events that do not introduce frameshift or PTC (3n no PTC); events that create a frameshift but without introducing a PTC (non-3n no PTC). The two latter categories are not detectable by NMD. AS rates in WT and in NMD-deficient cells were computed globally within each bin, as the proportion of AS reads among all reads spanning introns (or PCIs) from that bin. Error bars represent the 95% confidence interval (CI) of this proportion. a IR (n = 65,159 introns). b Splicing of PCIs (n = 1,383,067 PCIs)