Fig. 3
From: Depletion of somatic mutations in splicing-associated sequences in cancer genomes
Levels of somatic synonymous mutations in ESEs. a, b Levels of SSM at ESE and non-ESE (see ‘Methods’) in the tumours that were exome-sequenced (TCGA) or WGS (ICGC). Y-axis units, synonymous mutations per tumour per. b, c SSM from TCGA exomes (a) and ICGC WGS (b) were segregated into six equivalent classes of substitutions and normalised by the number of reference nucleotides. Statistical significance was computed using Wilcoxon signed rank test. The y-axis unit is SSM rate per bp per tumour. Error bars, 95% CI computed by bootstrapping