Skip to main content
Fig. 1 | Genome Biology

Fig. 1

From: Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Fig. 1

Levels of SSMs at splicing associated sequences are depleted across cancers in both exome and whole-genome sequence (WGS) data. a, b Levels of SSM at exonic ends and core in the tumours that were exome-sequenced (TCGA) or WGS (ICGC). Y-axis units, synonymous mutations per tumour. Error bars, 95% CI computed by bootstrapping. c, d Distribution of differences in SSM counts between flank and core within individual tumour that were exome-sequenced (TCGA) or WGS (ICGC). Statistical significance was computed using Wilcoxon signed rank test. The y-axis unit is SSM rate per bp per tumour

Back to article page