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Fig. 2 | Genome Biology

Fig. 2

From: f-scLVM: scalable and versatile factor analysis for single-cell RNA-seq

Fig. 2

Model validation using cycling mouse embryonic stem cells. Application of f-scLVM to 182 mESCs, experimentally staged for the cell cycle. a Bivariate visualization of the cells using the G2M checkpoint and P53 pathway factors. The inferred G2M checkpoint factor discriminates cells in G2/M phase from the remaining cell population. b Weights for the most important genes in the P53 pathways and G2M checkpoint factors, showing both genes that were pre-annotated by MSIGDB (black) and genes added by the model (red)

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