Skip to main content

Table 1 Conserved site selective editing in mammals

From: Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome

Substrate Edit sitea Percentage editing Reference to editing level Conserved adjacent stemb Stable adjacent stemc Length of EIE (nt) Number of base pairs in EIE Distance edit site–EIE (nt) 5′ EIE 3′ EIE
GluA2 Q/R 100 [31] Yes Yes 102 43 45   X
Gabra3 I/M 92 [31] Yes Yes 149 54 143   X
GluA3 R/G 91 [31] Yes Yes 81 32 220   X
FLNB Q/R 90 [52] No ND ND ND ND   
Htrc2 I/V 85 [31] Yes Yes 64 27 159   X
GluK2 Q/R 83 [31] Yes Yes 129, 60 42, 25 48, 32 X X
ADAR2 +24 82 [31] Yes Yes 86 37 60 X  
Cyfip2 K/E 75 [31] Yes Yes 116 47 138   X
GluA2 R/G 72 [31] Yes Yes 79 30 230   X
GluK1 Q/R 62 [31] Yes Yes 73 27 70   X
BLCAP Y/C 50 [53] Yes Yes 71, 59, 64 33, 26, 28 37, 90, 123 X  
IGFBP7 K/E 45 [54] No ND ND ND ND   
FLNA Q/R 43 [31] Yes Yes 105 36 38   X
Nova1 S/G 30 [47] No ND   ND ND   
KCNA1 I/V 25 [31] No ND   ND ND   
PLCH2 R/G 20 [47] No ND   ND ND   
TMEM63B Q/R 20 [47] No ND   ND ND   
CCNI R/G 15 [47] No ND   ND ND   
Azin1 S/G 10 [52] No ND   ND ND   
Copa I/V 10 [52] No ND   ND ND   
GPATCH8 K/R 10 [47] No ND   ND ND   
NCSTN S/G 7 [47] No ND   ND ND   
OSGEP I/M 7 [47] No ND   ND ND   
  1. aAmino acid change after A-to-I editing
  2. bConserved stem adjacent to edited site, predicted from mfold [37]
  3. cStable adjacent stem, as predicted from RNAfold, where high base-pairing probabilities are calculated from the minimum free energy of single sequences [38]
  4. ND not determined