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Table 1 Conserved site selective editing in mammals

From: Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome

Substrate

Edit sitea

Percentage editing

Reference to editing level

Conserved adjacent stemb

Stable adjacent stemc

Length of EIE (nt)

Number of base pairs in EIE

Distance edit site–EIE (nt)

5′ EIE

3′ EIE

GluA2

Q/R

100

[31]

Yes

Yes

102

43

45

 

X

Gabra3

I/M

92

[31]

Yes

Yes

149

54

143

 

X

GluA3

R/G

91

[31]

Yes

Yes

81

32

220

 

X

FLNB

Q/R

90

[52]

No

ND

ND

ND

ND

  

Htrc2

I/V

85

[31]

Yes

Yes

64

27

159

 

X

GluK2

Q/R

83

[31]

Yes

Yes

129, 60

42, 25

48, 32

X

X

ADAR2

+24

82

[31]

Yes

Yes

86

37

60

X

 

Cyfip2

K/E

75

[31]

Yes

Yes

116

47

138

 

X

GluA2

R/G

72

[31]

Yes

Yes

79

30

230

 

X

GluK1

Q/R

62

[31]

Yes

Yes

73

27

70

 

X

BLCAP

Y/C

50

[53]

Yes

Yes

71, 59, 64

33, 26, 28

37, 90, 123

X

 

IGFBP7

K/E

45

[54]

No

ND

ND

ND

ND

  

FLNA

Q/R

43

[31]

Yes

Yes

105

36

38

 

X

Nova1

S/G

30

[47]

No

ND

 

ND

ND

  

KCNA1

I/V

25

[31]

No

ND

 

ND

ND

  

PLCH2

R/G

20

[47]

No

ND

 

ND

ND

  

TMEM63B

Q/R

20

[47]

No

ND

 

ND

ND

  

CCNI

R/G

15

[47]

No

ND

 

ND

ND

  

Azin1

S/G

10

[52]

No

ND

 

ND

ND

  

Copa

I/V

10

[52]

No

ND

 

ND

ND

  

GPATCH8

K/R

10

[47]

No

ND

 

ND

ND

  

NCSTN

S/G

7

[47]

No

ND

 

ND

ND

  

OSGEP

I/M

7

[47]

No

ND

 

ND

ND

  
  1. aAmino acid change after A-to-I editing
  2. bConserved stem adjacent to edited site, predicted from mfold [37]
  3. cStable adjacent stem, as predicted from RNAfold, where high base-pairing probabilities are calculated from the minimum free energy of single sequences [38]
  4. ND not determined
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Genome Biology

ISSN: 1474-760X

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