Fig. 6
From: Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome
Structural requirements for efficient editing at the 5′ +4 site and 3′ +6 sites of the pri-miR-376a2 transcript. a Top: the miR-376 cluster constructs. Edited adenosines in the pri-miRNA stem loops are indicated with red dots and efficiently edited adenosines are shown with numbers indicating their position in the corresponding mature miRNAs. Mature miRNA sequences are indicated with blue lines. Below: sequences of different pre-miR constructs from the miR-376 cluster. WT indicates the full length of the cluster shown above. b Quantification of editing efficiency at the 5′ +4 site and 3′ +6 sites of the pri-miR-376a2 in the different constructs transfected into HeLa cells. The mean value of the ratio between the A and G peak heights from three individual experiments was calculated as percentage of editing. Error bars are standard deviation