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Fig. 3 | Genome Biology

Fig. 3

From: Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome

Fig. 3

Selectivity of editing at the Q/R site in GluA2. a Top: sites of editing and average percentage editing in the GluA2 reporter GA2Q/R co-transfected with an ADAR2 expression vector in HEK293 cells. Exon sequence is indicated in blue and the editing inducer element (EIE) shaded in grey. The Q/R site is indicated with a red dot. Bottom: sites of editing in the GluA2 reporter with the internal loop deleted (GA2Q/R-Δloop) co-transfected with ADAR2 in HEK293 cells. b Top: sites of editing and average percentage editing in the GluA2 reporter GA2Q/R co-transfected with the mutant ADAR2-EAA-E488Q expression vector in HEK293 cells. Bottom: sites of editing in the GluA2 reporter with the internal loop deleted (GA2Q/R-Δloop) co-transfected with ADAR2-EAA-E488Q in HEK293 cells. The mean value of the ratio between the A and G peak heights from three separate experiments was calculated as percentage editing

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