TY - JOUR AU - Daniel, Chammiran AU - Widmark, Albin AU - Rigardt, Ditte AU - Öhman, Marie PY - 2017 DA - 2017/10/23 TI - Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome JO - Genome Biology SP - 195 VL - 18 IS - 1 AB - Adenosine to inosine (A-to-I) RNA editing has been shown to be an essential event that plays a significant role in neuronal function, as well as innate immunity, in mammals. It requires a structure that is largely double-stranded for catalysis but little is known about what determines editing efficiency and specificity in vivo. We have previously shown that some editing sites require adjacent long stem loop structures acting as editing inducer elements (EIEs) for efficient editing. SN - 1474-760X UR - https://doi.org/10.1186/s13059-017-1324-x DO - 10.1186/s13059-017-1324-x ID - Daniel2017 ER -