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Fig. 3 | Genome Biology

Fig. 3

From: Systematic identification of regulatory variants associated with cancer risk

Fig. 3

Identification and validation of regulatory SNPs. a Distribution of effect sizes and DESeq2 p values for all the SNPs that have two alleles covered. b Distribution of effect sizes of all the tested SNPs against the activities of the SNP-containing regions. The regulatory SNPs in PREs are shown in red and those in NREs in blue. c Luciferase reporter assay validation of the estimated effect sizes for 14 regulatory SNPs. r represents the Pearson correlation coefficient. d Differences in predicted TF binding scores between two alleles for different classes of SNPs

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