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Fig. 7 | Genome Biology

Fig. 7

From: The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

Fig. 7

Co-localization of ERβ and AGO2 binding sites in the BC cell genome. a Heatmap summarizing co-localized AGO2 (green) and ERβ (red) binding sites in ERβ + (Ct- ERβ) and ERβ − (wild-type (wt)) MCF-7 cells, respectively. The right panel shows mean read densities in the four conditions displayed. b Distribution of ERβ–AGO2 binding sites with respect to the nearest transcription start site in ERβ + cells. c Observed vs expected distribution of ERβ–AGO2 binding sites within gene segments, calculated according to Genome Analyzer Tester. d Statistically enriched transcription factor binding motifs most enriched within ERβ–AGO2 binding sites

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