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Table 1 Editing values across 21 species

From: Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance

Organisma Tissue/Source Source readsb [% aligned] Hyper-editing reads Editing events Unique editing sites [% A-to-G of all types] Unique sites overlapping with coding regionsc [% of total] Unique sites overlapping with repeatsc [% of total]
Human Brain 64,313,204 [92] 22,117 117,383 75,984 [99] 31 [0] 70,160 [92]
Chimpanzee Brain 20,083,064 [66] 2327 10,866 9916 [95] 76 [1] 9089 [92]
Rhesus Brain 215,339,102 [87] 169,735 921,561 525,245 [91] 1796 [0] 499,388 [95]
Mouse Brain 114,374,684 [90] 5784 28,910 13,748 [94] 99 [1] 9497 [69]
Rat Brain 238,077,800 [84] 23,724 119,260 31,788 [87] 1096 [3] 23,562 [74]
Minke whale Brain 51,470,260 [94] 20,301 180,079 121,897 [100] 701 [1] 106,429 [87]
Cow Brain 208,706,410 [87] 70,520 389,830 200,770 [99] 1161 [1] 188,187 [94]
Sheep Brain 31,846,364 [91] 15,792 83,756 17,316 [93] 84 [0] 15,198 [88]
Opossum Brain 69,848,223 [65] 613 2926 2168 [90] 132 [6] 1786 [82]
Chicken Brain 269,226,888 [88] 24,690 169,793 79,728 [98] 2991 [4] 42,718 [54]
Lizard Brain 183,282,934 [60] 98,483 700,905 122,793 [98] 284 [0] 52,343 [43]
Frog Brain 51,896,478 [75] 54,519 388,744 147,172 [97] 180 [0] 69,943 [48]
Elephant shark Brain 139,569,606 [75] 67,704 449,965 200,171 [89]d 428 [0] 162,066 [81]
Purple sea urchin Young juvenile 76,613,634 [71] 36,570 216,215 83,594 [80]d 239 [0] 25,661 [31]
Octopus CNS 344,308,354 [86] 1,135,890 7,851,521 1,053,826 [99] - -
Sea hare (Aplysia) CNS 63,075,904 [77] 2952 23,757 12,546 [95] 2 [0] 936 [7]
Fly (Drosophila) Head 257,255,489 [97] 6124 57,065 39,472 [100] 1124 [3] 14,471 [37]
Nematode (C. elegans) Larvae 133,158,570 [97] 8691 65,543 21,713 [100] 244 [1] 11,782 [54]
Coral WT 65,782,768 [61] 47,546 314,345 127,069 [88] - -
Yeast (S. cerevisiae) WT 23,339,332 [99] 7 42 12 [63] - -
Thale cress (Arabidopsis) WT 49,166,984 [96] 5 26 11 [13] - -
  1. aAdditional details are given in the table in Additional file 2
  2. bAll samples were run as single-ended and strand-indifferent (for comparison reason)
  3. cWe annotated coding regions using xenoRefGene (RefSeq for Human and Frog) and repeats regions using RepeatMasker, both from the UCSC Genome Browser. Octopus and Coral were omitted from this analysis since their genomes and annotations are not available in the UCSC Genome Browser
  4. dA-to-C signal with sequencing error features was also identified in the sample; thus, for specificity calculations A-to-C sites were excluded