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Fig. 4 | Genome Biology

Fig. 4

From: Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance

Fig. 4

Evolution of the ADAR sequence preference, based on the sequence context (upstream and downstream adjacent locations) of the hyper-editing sites. The motifs cluster into two groups, largely consistent with their phylogeny: most vertebrates cluster together whereas amphibian and invertebrates cluster to a different group (with one exception, opossum, which has a small number of sites and possibly a noisy motif). In both clusters, G is depleted in the upstream nucleotide, whereas the downstream nucleotide preference is different for the two clusters. The first cluster exhibits a preference for G downstream, whereas in the other one A is preferred. (Red: over-representation; blue: under-representation). The downstream nucleotide preference is determined by the residue S486 (PDB structure 5HP2), as described by Matthews et al. [45]. Presented here for each organism are the amino acids observed at this position (see also Additional file 1: Figure S3). The five species exhibiting the most different 3' preference encode ADARs with a different amino acid in this position

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