Skip to main content
Fig. 4 | Genome Biology

Fig. 4

From: Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Fig. 4

Normal organ histology in the absence of ADAR1 RNA editing. a Hematoxylin and eosin (H&E)-stained sections of the indicated organs of Adar1 E861A/E861A Ifih1 -/- (n = 4; 2 male, 2 female) and Adar1 E861A/+ Ifih1 -/- (n = 4; 2 male, 2 female) control littermates. 10× magnification with 100-μM scale bar; 40× inset for each. bg MicroCT analysis of tibial bone; C57BL/6 (n = 4), Adar1 +/+ Ifih1 -/- (n = 4), Adar1 E861A/+ Ifih1 -/- (n = 7), Adar1 E861A/E861A Ifih1 -/- (n = 9). b Representative images of reconstructed trabecular region of the secondary spongiosa within the proximal tibia with color-coded quantitative mineralization from indicated genotypes. c Tibial length, (d) Trabecular bone volume, (e) trabecular number, (f) trabecular separation, and (g) trabecular thickness. hk MicroCT analysis of cortical bone of the same samples used for panels (bg). h Representative images of reconstructed cortical bone with color-coded quantitative mineralization, (i) cortical thickness, (j) cortical bone area, and (k) endocortical perimeter. Results are mean ± SEM; significance tested using ANOVA, *P < 0.05, **P < 0.01

Back to article page