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Fig. 2 | Genome Biology

Fig. 2

From: Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Fig. 2

Modest activation of ISG expression in Adar1 E861A/E861A Ifih1 -/- tissues. a Quantitative reverse transcription polymerase chain reaction (qRT-PCR) of four ISGs from tissues of 12-week-old mice, with the exception of the first panel comparing 12-week-old brain with E12.5 fetal brain from Adar1 E861A/E861A Ifih1 +/+ embryos. Data represent mean ± SEM (n = 3/genotype); all samples normalized to C57BL/6. b PB serum cytokine levels from indicated genotypes. Positive control = supernatant from tamoxifen treated R26-CreERT2 Adar1 E861A/fl hematopoietic cell line. Results are mean ± SEM; significance determined using two-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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