Fig. 2
From: Sparse conserved under-methylated CpGs are associated with high-order chromatin structure
Features of scUMCs. a–d Three groups of under-methylated features are color-coded: blue (conserved UMRs), red (scUMCs), and gray (non-conserved UMCs). a CpG density (normalized to 100 bp). b Percentage of features associated with either CGI or CGI shore. c Distribution of distances to TSSs. d Percentage of features associated with regulatory elements from ENCODE. Promoter and enhancer regions are defined by chromatin state segmentation (ChromHMM) from ENCODE as described in “Methods.” TFBSs are ChIP-seq peak clusters for 161 transcription factors (ENCODE). Promoter TFBS is the subset of TFBSs with overlapping promoter states. Enhancer TFBS is the subset of TFBSs with overlapping enhancer states. Distal TFBS is the subset of TFBS not overlapping chromHMM Promoter or Enhancer states. The error bar is the 95% confidence interval of percentage for nine cell lines involving chromatin state segmentation