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Table 2 Experimental evidence for the top 15 genes identified using ProGENI from the GDSC dataset for cisplatin, docetaxel, and doxorubicin

From: Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance

Gene symbol Rank (ProGENI) Rank (Pearson) Absolute value of Pearson correlation coefficient Evidence
Cisplatin
TUBB6 2 2 0.2759 Direct (this study)
DYNC2H1 3 4 0.2680 Direct (this study)
CLDN3 4 7 0.2602 Direct (literature)
SPARC 5 8 0.2574 Direct (literature)
GJA1 6 6 0.2623 Direct (literature)
ITGA5 7 11 0.2466 Direct (literature)
TPM2 8 9 0.2567 Direct (literature)
MMP2 9 37 0.2160 Direct (literature)
AXL 12 15 0.2373 Direct (literature)
ENG 13 47 0.2089 Direct (literature)
ELK3 14 13 0.2394 Direct (this study)
TIMP1 15 29 0.2207 Direct (literature)
FSCN1 1 1 0.2879 Not found
FHL3 10 10 0.2477 Not found
MMP14 11 39 0.2143 Not found
Docetaxel
CAV1 1 8 0.3713 Direct (literature)
YAP1 2 1 0.4148 Direct (literature)
AXL 6 2 0.4098 Direct (literature)
MMP14 7 22 0.3525 Direct (literature)
CYR61 9 6 0.3791 Direct (literature)
CAV2 10 16 0.3566 Direct (literature)
GNG12 11 5 0.3792 Direct (this study)
CTSB 12 27 0.3462 Direct (literature)
FSTL1 14 17 0.3557 Direct (this study)
ST5 15 7 0.3782 Direct (this study)
WWTR1 3 4 0.4075 Not found
PDGFC 4 13 0.3659 Not found
PTRF 5 3 0.4094 Not found
ITGB5 8 21 0.3534 Not found
PLAU 13 110 0.3033 Not found
Doxorubicin
ATF1 1 1 0.2000 Direct (this study)
MIS12 2 4 0.1887 Direct (this study)
OSBPL2 5 6 0.1865 Direct (this study)
CSNK2A1 7 1587 0.0752 Direct (literature)
PSIP1 (LEDGF) 8 46 0.1537 Direct (literature)
CAMK2A 9 6991 0.0157 Direct (literature)
CSNK2A2 10 4870 0.0347 Direct (literature)
GOSR1 11 6867 0.0167 Direct (this study)
MAPK8 13 7574 0.0112 Direct (literature)
SPI1 14 6287 0.0217 Direct (literature)
CREB1 15 665 0.1000 Direct (literature)
NOC3L 3 3 0.1893 Not found
IL27RA 4 2 0.1911 Not found
MGEA5 6 7 0.1814 Not found
WAPAL 12 8 0.1805 Not found
  1. The first column shows the gene symbols, the second column shows the rank of each gene using Robust-ProGENI, the third column shows the rank of each gene using the Pearson correlation scheme, the fourth column shows the absolute value of the PCC, and the fifth column shows the nature of the evidence