Table 2 Experimental evidence for the top 15 genes identified using ProGENI from the GDSC dataset for cisplatin, docetaxel, and doxorubicin
From: Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance
Gene symbol | Rank (ProGENI) | Rank (Pearson) | Absolute value of Pearson correlation coefficient | Evidence |
|---|---|---|---|---|
Cisplatin | ||||
  TUBB6 | 2 | 2 | 0.2759 | Direct (this study) |
  DYNC2H1 | 3 | 4 | 0.2680 | Direct (this study) |
  CLDN3 | 4 | 7 | 0.2602 | Direct (literature) |
  SPARC | 5 | 8 | 0.2574 | Direct (literature) |
  GJA1 | 6 | 6 | 0.2623 | Direct (literature) |
  ITGA5 | 7 | 11 | 0.2466 | Direct (literature) |
  TPM2 | 8 | 9 | 0.2567 | Direct (literature) |
  MMP2 | 9 | 37 | 0.2160 | Direct (literature) |
  AXL | 12 | 15 | 0.2373 | Direct (literature) |
  ENG | 13 | 47 | 0.2089 | Direct (literature) |
  ELK3 | 14 | 13 | 0.2394 | Direct (this study) |
  TIMP1 | 15 | 29 | 0.2207 | Direct (literature) |
  FSCN1 | 1 | 1 | 0.2879 | Not found |
  FHL3 | 10 | 10 | 0.2477 | Not found |
  MMP14 | 11 | 39 | 0.2143 | Not found |
Docetaxel | ||||
  CAV1 | 1 | 8 | 0.3713 | Direct (literature) |
  YAP1 | 2 | 1 | 0.4148 | Direct (literature) |
  AXL | 6 | 2 | 0.4098 | Direct (literature) |
  MMP14 | 7 | 22 | 0.3525 | Direct (literature) |
  CYR61 | 9 | 6 | 0.3791 | Direct (literature) |
  CAV2 | 10 | 16 | 0.3566 | Direct (literature) |
  GNG12 | 11 | 5 | 0.3792 | Direct (this study) |
  CTSB | 12 | 27 | 0.3462 | Direct (literature) |
  FSTL1 | 14 | 17 | 0.3557 | Direct (this study) |
  ST5 | 15 | 7 | 0.3782 | Direct (this study) |
  WWTR1 | 3 | 4 | 0.4075 | Not found |
  PDGFC | 4 | 13 | 0.3659 | Not found |
  PTRF | 5 | 3 | 0.4094 | Not found |
  ITGB5 | 8 | 21 | 0.3534 | Not found |
  PLAU | 13 | 110 | 0.3033 | Not found |
Doxorubicin | ||||
  ATF1 | 1 | 1 | 0.2000 | Direct (this study) |
  MIS12 | 2 | 4 | 0.1887 | Direct (this study) |
  OSBPL2 | 5 | 6 | 0.1865 | Direct (this study) |
  CSNK2A1 | 7 | 1587 | 0.0752 | Direct (literature) |
  PSIP1 (LEDGF) | 8 | 46 | 0.1537 | Direct (literature) |
  CAMK2A | 9 | 6991 | 0.0157 | Direct (literature) |
  CSNK2A2 | 10 | 4870 | 0.0347 | Direct (literature) |
  GOSR1 | 11 | 6867 | 0.0167 | Direct (this study) |
  MAPK8 | 13 | 7574 | 0.0112 | Direct (literature) |
  SPI1 | 14 | 6287 | 0.0217 | Direct (literature) |
  CREB1 | 15 | 665 | 0.1000 | Direct (literature) |
  NOC3L | 3 | 3 | 0.1893 | Not found |
  IL27RA | 4 | 2 | 0.1911 | Not found |
  MGEA5 | 6 | 7 | 0.1814 | Not found |
  WAPAL | 12 | 8 | 0.1805 | Not found |