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Fig. 5 | Genome Biology

Fig. 5

From: Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance

Fig. 5

Agglomerative clustering results applied to all drugs and their Robust-ProGENI identified genes from the GDSC dataset. a Clusters formed for drugs and genes. Rows of the matrix correspond to different drugs and columns correspond to different genes. Only columns (genes) with variance larger than 0.1 were used in the analysis (1177 genes). be Enriched pathways identified for four clusters of genes using DAVID. Pathways with Benjamini–Hochberg-corrected p value <0.1 were sorted based on the number of shared genes and top entries were kept. Columns correspond to genes and rows correspond to pathways, with red indicating that the gene is annotated with that pathway name

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