Table 2 QTLs for immune gene modules
From: An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
Module | Top SNP | Chr | Hg19 pos. (Mb) | Allele (minor/major) | MAF (avg) | P value DILGOM07 (effect size) | P value YFS (effect size) | Meta P value |
|---|---|---|---|---|---|---|---|---|
VRM | rs182710579 | 4 | 19768086 | G/T | 0.012 | 2.01 × 10–4 (0.05) | 8.10 × 10–6 (0.02) | 9.23 × 10–9 |
rs151234502 | 7 | 148950168 | T/C | 0.012 | 2.59 × 10–1 (0.01) | 5.31 × 10–9 (0.03) | 2.46 × 10–8 | |
rs147742798 | 11 | 70947761 | T/C | 0.016 | 1.51 × 10–3 (0.04) | 1.66 × 10–6 (0.02) | 9.43 × 10–9 | |
BCM | rs2523489 | 6 | 31348878 | T/C | 0.186 | 1.42 × 10–1 (0.005) | 5.29 × 10–8 (0.006) | 6.27 × 10–8 |
PM | rs1354034 | 3 | 56849749 | T/C | 0.284 | 7.11 × 10–14 (-0.02) | 1.51 × 10–16 (-0.008) | 7.35 × 10–28 |
rs28367734 | 6 | 3128657 | A/G | 0.108 | 5.40 × 10–4 (0.02) | 2.02 × 10–5 (0.006) | 5.44 × 10–8 | |
NM | rs2485364 | 6 | 159512260 | C/T | 0.466 | 1.78 × 10–3 (0.009) | 6.05 × 10–7 (0.004) | 3.93 × 10–9 |
rs13297295 | 9 | 131659724 | C/T | 0.085 | 4.26 × 10–2 (0.009) | 8.39 × 10–11 (0.01) | 3.93 × 10–11 | |
rs140929198 | 20 | 38555870 | A/G | 0.031 | 2.98 × 10–2 (0.03) | 8.47 × 10–9 (0.01) | 1.41 × 10–9 | |
GIMA | rs2185366 | 8 | 131342722 | T/C | 0.421 | 2.0 × 10–2 (0.007) | 1.52 × 10–6 (0.004) | 1.05 × 10–7 |