Fig. 6
From: Population and allelic variation of A-to-I RNA editing in human transcriptomes
Impact of edQTL SNPs on RNA secondary structure. a Cumulative distribution plot comparing the absolute value of the distance between SNP–RNA editing site pairs for significant edQTL SNPs and control SNPs within the computationally predicted RNA secondary structure of the IRAlu hairpin. b Cumulative distribution plot comparing the absolute value of the change in the number of paired bases for significant edQTL SNPs and control SNPs. c Cumulative distribution plot comparing the absolute value of the change in free energy of the predicted RNA secondary structure for significant edQTL SNPs and control SNPs. The Kolmogorov–Smirnov test was used for the cumulative distribution plots. Two examples of SNPs that significantly alter RNA editing levels: SNP on the opposite Alu to the RNA editing site in NDE1 (d) and SNP on the same Alu as the RNA editing site in H2AFV (e). Cartoon representation of the IRAlu hairpins and computationally predicted RNA secondary structures (left). Detailed base-pairing structures (right)