Fig. 4
From: Population and allelic variation of A-to-I RNA editing in human transcriptomes
RNA editing of ATM is genetically associated with response to metformin. a Box plot showing the significant association of SNP rs227091 with editing level (Φ) at chr11:108237832 within the CEU population. Each dot represents data from a particular individual and the size of each dot indicates the number of reads covering the RNA editing site in that individual. b ASED allele-specific editing level (Φ) of chr11:108237832 with respect to SNP rs227091 within the CEU population. Error bars represent likelihood-ratio test-based 95% confidence intervals of RNA editing levels inferred from read counts. Average allelic Φ values are represented in parentheses. c LD plot showing a GWAS signal (response to metformin; green) linked with edQTL (purple) and ASED (orange) SNPs in ATM. d Heatmap of edQTL significance for six cis-regulated RNA editing sites in ATM along with seven cis SNPs. The values in the heatmap represent − log(p value) for the association between a given RNA editing site and a given SNP within the given population