Fig. 2

ASED analysis to identify cis-regulated RNA editing events. a Schematic diagram of ASED analysis. Heterozygous SNPs are used to assign RNA-seq reads to specific alleles. b Example of allele-specific RNA editing in the NDE1 gene. ASED analysis of RNA editing site chr16:15795035 with respect to heterozygous SNP rs8048427. c Cis-regulated RNA editing sites in the CEU population. edQTL and ASED of CEU as well as multiple replicates of GM12878 were used. The three circles outside of the Venn diagram represent RNA editing sites that were not considered in the other two analyses due to preliminary filters and method-specific limitations. d Example of a cis-regulated RNA editing site in ZDHHC20 associated with a rare variant, called with ASED analysis of multiple RNA-seq replicates from one individual, GM12878. Error bars represent likelihood-ratio test-based 95% confidence intervals of RNA editing levels inferred from read counts. Average allelic Φ values are represented in parentheses