Fig. 7

Incorporating known cell correspondence information to compute shared master time. a Scatterplot of shared master time inferred from both gene expression and DNA methylation (x-axis) and master time inferred using DNA methylation only (y-axis). b Scatterplot of shared master time inferred from both gene expression and DNA methylation (x-axis) and master time inferred using gene expression only (y-axis). c Plot showing “lagging cells” whose shared master time values overlap with the master time values of a previous time point. The x-values are jittered to mitigate overplotting. Colored horizontal lines indicate the maximum master time value for the corresponding time point. Lagging cells are indicated by “x” symbols. d Plot showing differences between lagging cells identified from shared master time and lagging cells identified from gene expression master time alone. The “x” symbols indicate lagging cells identified using shared master time. Arrows indicate two cells that are lagging based on gene expression master time alone but not shared master time. e Plot showing differences between lagging cells identified from shared master time and lagging cells identified from DNA methylation master time alone. The “x” symbols indicate lagging cells identified using shared master time