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Fig. 5 | Genome Biology

Fig. 5

From: ReMixT: clone-specific genomic structure estimation in cancer

Fig. 5

Tracking clonal expansions in xenograft passages. a Breakpoints identified by ReMixT as clone-specific were classified according to their clonal prevalence change between SA501X1A and replicate xenograft passages SA501X3A and SA501X3F. All breakpoints could be classified as ascending in both SA501X3A and SA501X3F, descending in both, or stable in at least one. Shown are the clonal prevalence changes between pairs of samples for which WGS was available. b Relationship between primary tumour sample T and xenograft passages X*. c Accuracy of copy number inference for X3F based on single cell whole genome sequencing. Shown is the proportion of regions with correctly predicted copy number (y-axis) for each clone A copy number (x-axis), split between clonal and subclonal (blue/green) as determined from single cell data. d Copy number profile (top) for chromosomes 7 and 15 showing corroboration between single cell (bottom) and ReMixT (middle) subclonal copy number prediction. Yellow flags show the location of translocation breakpoints predicted to be subclonal by ReMixT. e Similarly, chromosomes 1/18 translocation breakpoints predicted to be subclonal by ReMixT. Copy number plots show raw major (red) and minor (blue) copy numbers

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