Fig. 1
From: ReMixT: clone-specific genomic structure estimation in cancer
An overview of the ReMixT Method. a) Bulk sequencing is applied to a mixture of cells modeled as a set of clones of unknown proportion each with distinct sets of chromosomes with unknown structure. b) Observed data include binned read counts per segment, and rearrangement breakpoints connecting segment ends. c) The ReMixT graphical model as a factor graph. d) Calculation of the transition factor involves calculating the number of telomeres t, the number of segment ends left unconnected to another segment end in the model