Fig. 2

BRIE improves isoform estimates by using an informative prior on simulated data. a, b At very low coverage RPK=25, a scatter plot between the estimates of the exon inclusion ratios by BRIE and the simulation truth. a BRIE.Null uses five random uniformly distributed features to learn the prior. b BRIE uses one correlated feature with Pearson’s R=0.8 to the truth to learn an informative prior. c Pearson’s R between truth and estimate by BRIE, BRIE.Null, and three other methods for different coverages. RPK reads per kilobase