Fig. 3
NicE-seq and validation of NicE-seq in fixed and native cells. a The different steps involved in labeling and capture of open chromatin sites using NicE-seq. b A Venn diagram showing the overlap between the OCSs identified using fixed and native HCT116 cells. c A screenshot of the IGV browser showing the overlap between OCSs identified in native (top panel in red) and fixed (bottom panel in blue) HCT116 cells in a 66-kb window. d A Venn diagram showing overlap between OCSs identified from HCT116 and MCF7 cell lines. e Snapshot of IGV browser showing overlap of OCS peaks (top panel in blue for HCT116 and bottom panel in red for MCF7) in a 75-kb window. f The log2 fold change of OCS peaks in different genomic regions for HCT116 (purple) and MCF7 (green) cells