TY - JOUR AU - Zhang, Ying AU - Tang, Chong AU - Yu, Tian AU - Zhang, Ruirui AU - Zheng, Huili AU - Yan, Wei PY - 2017 DA - 2017/06/15 TI - MicroRNAs control mRNA fate by compartmentalization based on 3′ UTR length in male germ cells JO - Genome Biology SP - 105 VL - 18 IS - 1 AB - Post-transcriptional regulation of gene expression can be achieved through the control of mRNA stability, cytoplasmic compartmentalization, 3′ UTR length and translational efficacy. Spermiogenesis, a process through which haploid male germ cells differentiate into spermatozoa, represents an ideal model for studying post-transcriptional regulation in vivo because it involves a large number of transcripts that are physically sequestered in ribonucleoprotein particles (RNPs) and thus subjected to delayed translation. To explore how small RNAs regulate mRNA fate, we conducted RNA-Seq analyses to determine not only the levels of both mRNAs and small noncoding RNAs, but also their cytoplasmic compartmentalization during spermiogenesis. SN - 1474-760X UR - https://doi.org/10.1186/s13059-017-1243-x DO - 10.1186/s13059-017-1243-x ID - Zhang2017 ER -