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Fig. 5 | Genome Biology

Fig. 5

From: Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements

Fig. 5

Pax3 and FoxO1 enhancers located downstream of the RH30 breakpoint. a At 11.5 dpc, B38Z-Foxo1 drives expression in the embryonic vasculature, a hindlimb rostral domain, AER, stomach and gut. Myotomal expression is faint and masked by the vascular expression; B61Z-Foxo1 expresses in all these domains excluding the vasculature; B38Z-Foxo1-RH30∆ is not able to drive vascular or myotomal expression. b Map showing the position of enhancer regions identified downstream of the RH30 translocation breakpoint. The three BAC clones are represented as black bars with their given names. Different coloured boxes represent the location of different enhancer regions within the BACs. c Deletion of sequences downstream the RH30 breakpoint in B30Z-Pax3 do not result in a pattern change

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Genome Biology

ISSN: 1474-760X

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