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Fig. 6 | Genome Biology

Fig. 6

From: N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Fig. 6

Pyknon expression across tissues and tissue states. ae Pyknon clusters showing tissue and disease specificity among normal (a, b) or diseased (ce) tissue samples. a, c Heatmaps of standardized pyknon expression profiles. Dendrograms were constructed with Hierarchical Clustering using Pearson correlation as a metric. b, d Principal component analysis (PCA) of the normal (b) or the diseased (d) samples. The X-axis corresponds to the first principal component (PC1) and the Y-axis to the second principal component (PC2). The numbers next to the PC labels represent the amount of information from the original dataset that is projected on each one. e Partial Least Squares-Discriminant Analysis showing the perfect separation of the samples with normal (CLL-NFZ) or aberrant (CLL-AFZ) FISH profile of chromosome arm 17p and ZAP-70 levels. CRC-MSS colorectal cancer sample without microsatellite instability, CRC-MSI colorectal cancer sample with microsatellite instability, Lympho B-lymphocytes, NBreast normal breast tissue, NColon normal colon tissue, NHeart normal heart tissue, NLiver normal liver tissue, NLung normal lung tissue, NSMuscle normal skeletal muscle tissue, NTesticle normal testicle, PBMC mononuclear cells. f The COX OS analyses of the pyknon expression using the genome-wide array identified a set of six transcribed pyknons that are associated at a p < 0.01 with OS in CRC. All these six probes were chosen for the analyses because they correspond to an unambiguous genomic location. The blue bars correspond to a negative HR, meaning an association with good prognosis, while the red bar correspond to a positive HR, meaning an association with poor prognosis. g Expression of probed pyknons in comparison with human miRNAs. Pyknon transcription levels are higher than those of miRNAs—probability density values of normalized intensities for the miRNA and pyknon probes across all 165 CRC arrays used for the data from Fig. 6f

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