Fig. 2

Major histocompatibility complex allele associations with autoimmune and infectious diseases. a Abbreviations marked with an asterisk indicate the autoimmune disease showing the strongest association with the specific locus. b Single nucleotide polymorphisms (SNPs) and alleles in the major histocompatibility complex (MHC) shared between autoimmune and infectious diseases. The blue area shows MHC alleles located in the class I region and the green area shows those in the class II region. The blue arrows indicate either a protective effect of the genetic variants against the infectious disease or a slower progression to the infectious disease. The red arrows indicate increased susceptibility to the corresponding autoimmune or infectious disease. AIDS acquired immunodeficiency syndrome, AS ankylosing spondylitis, CD Crohn’s disease, CeD celiac disease, DM dermatomyositis, HBV hepatitis B virus, HCV hepatitis C virus, HIV human immunodeficiency virus, MS multiple sclerosis, Ps psoriasis, RA rheumatoid arthritis, SLE systemic lupus erythematosus, T1D type 1 diabetes, TB tuberculosis, UC ulcerative colitis, HPV human papilloma virus