Fig. 4

Increased clearance half-life on samples harboring kelch13 E252Q and kelch10 P623T mutations. Boxplots on the left illustrate the distribution of clearance half-life on samples with the E252Q kelch13 mutation and either with (green) or without (white) the kelch10 P623T mutation. The boxplot on the right represents the distribution of the same phenotype on samples harboring wild-type (WT) kelch13. Box boundaries represent the first and third quartiles and the length of whiskers corresponds to 1.5 times the interquartile range. The difference between distributions shown in each boxplot was evaluated by a Wilcoxon rank sum test