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Fig. 1 | Genome Biology

Fig. 1

From: SCALE: modeling allele-specific gene expression by single-cell RNA sequencing

Fig. 1

Allele-specific transcriptional bursting and gene categorization by single-cell ASE. a Transcription from DNA to RNA occurs in bursts, where genes switch between the “ON” and the “OFF” states. k on , k off , s, and d are activation, deactivation, transcription, and mRNA decay rate in the kinetic model, respectively. b Transcriptional bursting of the two alleles of a gene give rise to cells expressing neither, one, or both alleles of a gene, sampled as vertical snapshots along the time axis. Partially adapted from Reinius and Sandberg [6]. c Empirical Bayes framework that categorizes each gene as silent, monoallelic and biallelic (biallelic bursty, one-allele constitutive, and both-alleles constitutive) based on ASE data with single-cell resolution

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