Fig. 5

Comparing model predictions to chromatin dynamics data. This figure shows predicted (solid lines) and measured (dots) mean-square displacements (MSD) of single chromatin loci as function of time interval. a MSD of six loci on chromosome 4 and the MAT locus on chromosome 3, over time intervals of 1–150 s (main plot, data from [65]) or 1–10 s (inset, data from [66]). For each of the two datasets, a single time step parameter was fitted once to align simulation time with experimental time. The genomic distance of each locus to the centromere is indicated in the legend. b–e MSD of four loci on four different chromosomes, over time intervals in the range of 16 ms to 100 s, on a double logarithmic scale. The chromosome number and the genomic distance of the locus to the centromere are indicated on top of each panel. Data (dots) are measurements from time-lapse microscopy in [64]. Green curves are model predictions. Dashed black lines show a subdiffusive power law MSD ∝ t ^0.5 as expected from the Rouse model [22, 37, 41]