Skip to main content

Table 1 Excessive mutation of MTBC gene sets that are likely targets of positive selection

From: The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

 

4+ effective drugs

<4 effective drugs

Gene set

Na

Excessive mutationb

Excess NSYc

Excessive mutation

Excess NSY

Drug resistanced

13

0/100 (0.501)

0/0 (1.000)

5/87 (0.001)

5/5 (0.177)

Drug resistance associatede,f

166

10/100 (0.545)

4/10 (0.987)

6/87 (0.946)

6/6 (0.121)

Mycolate superpathwayg

54

3/100 (0.881)

1/3 (0.964)

5/87 (0.229)

3/5 (0.876)

MTBC T-cell antigensh

300

14/100 (0.153)

10/14 (0.426)

6/87 (0.550)

6/6 (0.121)

  1. aNumber of genes in the gene set
  2. bProportion of mutations in gene set, p value calculated with a one-sided binomial test
  3. cProportion of NSY mutations in gene set, p value calculated with a one-sided binomial test
  4. d[73]
  5. e[38]
  6. f[39]
  7. g[55]
  8. h[74]