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Fig. 5 | Genome Biology

Fig. 5

From: The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

Fig. 5

Efficacious treatment leads to a predominance of purifying selection of MTBC populations. a The proportion of nonsynonymous to synonymous mutations (pNS) for observed fixed SNPs in each patient (N = 12). We used computer simulation to estimate the outcome of mutating the same codons as were affected in patients but under a neutral scenario of genetic drift. b pNS calculated for each efficaciously treated patient at each time point (N = 30) with the corresponding neutral estimate. Patients given efficacious treatment show a pNS that is lower than expected in the absence of selection. c pNS calculated for each non-efficaciously treated patient at each time point (N = 21) with the corresponding neutral estimate. Patients given non-efficacious treatment do not show a significant decrease of pNS when compared to the expectation of no selection. All reported p values were calculated with the Mann Whitney U-test comparing the observed pNS to a simulated result generated using the assumption of genetic drift. n.s. not significant

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