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Fig. 1 | Genome Biology

Fig. 1

From: SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Fig. 1

Sample-specific bias of read ratios due to sequencing quality metrics of the tumor–normal pair. a The three types of adjacent bins. Differences in ratio density (RD) of adjacent bins spanning on-target regions, off-target regions, or both demonstrating b similar distributions, c dissimilar distributions not centered at 0, or d dissimilar distributions centered on 0. e Mean RD compared to the difference of fold enrichment (log10 scale) between the tumor–normal pairs for 989 TCGA breast cancer samples. f Standard deviation of the RD compared to the difference in the library size (×106) for 989 TCGA breast cancer samples

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