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Fig. 1 | Genome Biology

Fig. 1

From: CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA

Fig. 1

Flowchart of CancerLocator. Step 1: A set of solid tumor samples and healthy plasma samples collected from public databases and the literature are used to select the informative features (CpG clusters) that can differentiate tumor types or healthy plasma samples. Then the beta distributions of the methylation levels of these selected features for each tumor type or healthy plasma samples are learnt. Step 2: Given a plasma sample, the methylation profile of its cfDNAs is measured by whole-genome bisulfite sequencing, which is then used as input for cancer location prediction by CancerLocator

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