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Fig. 3 | Genome Biology

Fig. 3

From: Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

Fig. 3

Dietary restriction (DR) attenuated age-related changes in DNA methylation. a, b Scatterplot comparison of bin-wise differences between diets at old age and age-related changes under ad libitum (AL) (a) and DR (b) conditions. Data density (red) is indicated on the axes. Blue line represents the linear regression line. Dashed lines mark the two standard deviations (2*σ) cutoff (±9.68% methylation difference). Formulas for linear regression and Pearson correlation coefficients are indicated. c Beanplot representation of methylation levels of 439 hypomethylated (left panel) and 132 hypermethylated (right panel) age-related differentially methylated regions (DMRs) ameliorated by DR in young and old mouse livers. Solid lines represent group-wise means; density curves are scaled. d Gene ontology and reactome enrichment of genes with age-related DMRs ameliorated by DR

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Genome Biology

ISSN: 1474-760X

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